TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review: V. Solitano et al.
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V Solitano, MM Estevinho, F Ungaro, F Magro…
BioDrugs, 2025
Springer
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), remains challenging to manage, with a substantial proportion of patients not responding to conventional therapies or developing complications. The tumor necrosis factor (TNF) superfamily member TL1A has emerged as an important player in the pathogenesis of IBD, influencing pathways of inflammation and fibrosis. This leading article reviews the role of TL1A in IBD, evaluates the efficacy of anti-TL1A therapies in clinical trials …
