Recent advances in our understanding of the vitamin D endocrine system.
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HF De Luca
The Journal of Laboratory and Clinical Medicine, 1976
europepmc.org
Vitamin D3 gives rise to at least one hormone in which the kidney is utilized as an endocrine system. This hormone arises from 25-OH-D3 which in turn is synthesized in the liver from vitamin D3. The production of this calcium and phosphorus mobilizing hormone, namely 1, 25-(OH) 2D3, is strongly regulated by the need for calcium and phosphorus. The regulation of its production can occur only after initial 1, 25-(OH) 2D3 is made and brings about the appearance of 25-OH-D3-24hydroxylase. The need for calcium brings about a stimulation of …
