Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomeline
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/10497134
其他信息:
PMID: 10497134
作者: B J Ring; S A Wrighton; S L Aldridge; K Hansen; B Haehner; ...
摘要: The involvement of flavin-containing monooxygenases (FMOs) in the formation of xanomeline N-oxide was examined in various human and rat tissues. Expressed FMOs formed xanomeline N-oxide at a significantly greater rate than did expressed cytochromes P-450. Consistent with the involvement of FMO in the formation of xanomeline N-oxide in human liver, human kidney, rat liver, and rat kidney microsomes, this biotransformation was sensitive to heat treatment, increased at pH 8.3, and inhibited by meth...
