Solbinsiran, a durable GalNAc-conjugated siRNA targeting ANGPTL3 in adults with mixed dyslipidaemia (PROLONG-ANG3): lessons from a randomized, placebo …
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D Llop, KK Ray
2026
academic.oup.com
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide, driven by lifelong accumulation of cholesterol carried by apolipoprotein B (apoB)-containing lipoproteins into the arterial wall. In the normotriglyceridaemic state, lowdensity lipoprotein particles (LDL-P) constitute approximately 90% of circulating apoB-containing particles; consequently, reducing LDL-P number and their cholesterol content (LDL-C) has been the cornerstone of lipid-lowering therapies. Despite substantial reductions in LDL-C …
