Hyperstable, Minimal-Length, and Blunt-Ended Collagen Heterotrimers
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DOI:
文献链接: https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202503353
其他信息:
T Fiala, P Bittner, R Heeb, V Islami, C Söll…
… (International ed. in …
pubmed.ncbi.nlm.nih.gov
Most natural collagens are heterotrimers-triple helices formed from three non-identical peptide strands. The design of synthetic heterotrimeric collagen is challenging since a mixture of three different peptides can form as many as 27 unique triple helices. Here, we present a general method for the assembly of collagen heterotrimers with a wide range of lengths, thermal stabilities, and strand arrangements driven by complementary interstrand salt bridges between (2S, 4S)-4-aminoproline and aspartate residues. We show how kinetic …
