Negative effects during placebo treatment: a systematic review and meta-analysis
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T Bschor, J Unger, L Nagel, G Schwarzer…
JAMA …, 2025
jamanetwork.com
Importance Analyzing effects within placebo groups allows for transdiagnostic comparisons, as placebo is the only substance systematically studied across all major psychiatric diagnoses. Recently, the study team meta-analytically showed that improvement under placebo varies across major psychiatric diagnoses. However, comprehensive transdiagnostic comparisons of negative effects under placebo (nocebo effects) are lacking. Objective To compare premature study termination rates in placebo groups of high-quality …
