Amylin receptor subunit interactions are modulated by agonists and determine signaling
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DOI:
文献链接: DOI: 10.1126/scisignal.adt8127
其他信息:
SE Gostynska, JA Karim, BE Ford, PH Gordon…
Science …, 2025
science.org
Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY1R, AMY2R, and AMY3R are heterodimers consisting of the calcitonin receptor (CTR), a G protein–coupled receptor, paired with a RAMP1, RAMP2, or RAMP3 accessory subunit, respectively, which increases amylin potency. Here, we found that the AMYRs had distinct basal subunit equilibria that were modulated by peptide agonists and determined the extent of cAMP signaling …
