Research progress in pharmacological mechanisms, structure-activity relationship and synthesis of sartans
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DOI:
文献链接: https://doi.org/10.2174/0929867329666220829101436
其他信息:
YF Wang, XY Ren, W Zhang…
Current Medicinal …, 2023
ingentaconnect.com
The sartans are a new class of antihypertensive drugs as angiotensin II receptor blockers which possess plenty of advantages in treating hypertension and related pathologies. This review describes the clinical treatment, side effects, and potential therapeutic effects of sartans from 1995 to date. The synthesis, structural-activity and molecular docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimidazole derivatives and other compounds are also described. With a clear Structure-Activity Relationship and abundant …
