Type 2 Immunity Promotes Neonatal Lung Progenitor Developmental Activity Through the STAT6 Signaling Axis
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CC Liao, CJ Chiu, BL Chiang
Allergy, 2025
Wiley Online Library
To the Editor, The immune environment of the neonatal lungs is biased toward type 2 immunity, characterized by the transient accumulation of type 2 cytokines and cells [1]. We observed transient elevation of the type 2 cytokines IL-13 and IL-33 and the immunoregulatory cytokine IL-10 in neonatal lungs from postnatal Days 1 to 4, which decreased with age. In contrast, the type 1 cytokine IFN-γ was less abundant in neonates and relatively increased in adults (Figure 1A, B). Given that neonatal lungs undergo active …
