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Case study: parecoxib: a prodrug of valdecoxib复制

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DL Teagarden, S Nema
Prodrugs: Challenges and Rewards Part 1, 2007
Springer
Parecoxib, a weakly acidic drug (pKa 4.9), was developed as a COX-2 inhibitor for the management and treatment of acute pain. It was designed to be a water-soluble (

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