Engineering a non-oxidative glycolysis pathway in industrial Bacillus licheniformis for carbon-efficient production of acetyl-CoA derived biochemicals
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J Zhu, J Kang, M Liu, Y Li, Y Wu, Y Zhan, P He…
Chemical Engineering …, 2026
Elsevier
Due to its high efficiency, sustainability, and environmental friendliness, microbial biomanufacturing has evolved into an attractive pattern for producing various biochemicals. However, CO 2 loss during acetyl-CoA formation from pyruvate fundamentally limits the carbon atom economy in biorefinery processes. In this study, a carbon conservation pathway was established in industrial Bacillus licheniformis DW2 to boost the generation of acetyl-CoA from glucose. Initially, a synthetic non-oxidative glycolysis (NOG) route was constructed …
