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Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction复制

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DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/1828071复制

其他信息:

PMID: 1828071
作者: D J Dripps; B J Brandhuber; R C Thompson; S P Eisenberg; D J Dripps; ...
摘要: The interleukin-1 receptor antagonist (IL-1ra) is a protein capable of inhibiting receptor binding and biological activities of IL-1 without inducing an IL-1-like response. Equilibrium binding and kinetic experiments show that IL-1ra binds to the 80-kDa IL-1 receptor on the murine thymoma cell line EL4 with an affinity (KD = 150 pM) approximately equal to that of IL-1 alpha and IL-1 beta for this receptor. However, IL-1ra is unable to induce two early events associated with IL-1 activity. Surfac...

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