Extended-release pramipexole in advanced Parkinson disease: a randomized controlled trial
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DOI:
文献链接: https://doi.org/10.1212/WNL.0b013e31822affdb
其他信息:
AHV Schapira, P Barone, RA Hauser, Y Mizuno…
Neurology, 2011
neurology.org
Background: In advanced Parkinson disease (PD), immediate-release pramipexole, taken 3 times daily, improves symptoms and quality of life. A once-daily extended-release formulation may be an effective and simple alternative therapy. Methods: For a multicenter randomized, double-blind, parallel trial of extended-and immediate-release pramipexole vs placebo, patients experiencing motor fluctuations while taking levodopa underwent flexible study drug titration and then maintenance at optimized dosage (0.375–4.5 mg/day). The …
