Single-virus Sequencing at Ultra-high Throughput for Novel Virus Discovery
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Y Shi
2022
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Background: Viruses are the most prevalent biological entities on earth and play a significant role in all habitats. Despite the recent blooming of viral metagenomics, capturing viral diversity remains inefficient due to the inherent quantitative enormity and genetic complexity. Single-virus sequencing has recently emerged as a powerful approach to disentangling the genetic complexity of the virus community to the minimum level, the single virus. However, this technology is still in its early stage with various limitations, including low …
