PET-Guided Modeling of Mucosal Boron Heterogeneity Improves Dose–Toxicity Prediction in BNCT
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YC Teng, Y Cao, X Zhu, L Huo, J Hong, X Lin…
International Journal of …, 2026
Elsevier
Purpose To evaluate whether mucosal boron heterogeneity measured using fluoro-boronophenylalanine positron emission tomography (18 F-BPA PET) improves the prediction of oral mucositis in boron neutron capture therapy (BNCT), and to establish an imaging-guided framework for normal tissue complication probability (NTCP) modeling. Methods and Materials This retrospective study analyzed 45 BNCT treatment sessions for head and neck cancer. Pre-treatment 18 F-BPA PET was used to quantify PET-derived …
