Suppression of gastric acid with intravenous esomeprazole and omeprazole: results of 3 studies in healthy subjects.
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K Röhss, C Wilder-Smith, J Kilhamn…
… journal of clinical …, 2007
europepmc.org
Objective To identify the optimal pharmacodynamic dosing regimen for esomeprazole administered intravenously (iv) and to compare acid suppression with various esomeprazole iv and omeprazole iv dosing regimens. Methods A total of 90 healthy Helicobacter pylori-negative subjects participated in three randomized, crossover studies of esomeprazole iv Comparative acid output study: an open-label study that compared single 40 mg iv doses (administered over 30 min) of esomeprazole and omeprazole. Dose-ranging study: an open …
