In vivo chimeric antigen receptor (CAR)-T cell therapy
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A Bot, A Scharenberg, K Friedman, L Guey…
Nature Reviews Drug …, 2025
nature.com
Chimeric antigen receptor (CAR)-T cell therapy has transformed the outcomes of patients with haematological malignancies, yet its use is limited by labour-intensive manufacturing, constrained production capacity and variable clinical performance. In vivo CAR-T cell engineering, in which CAR-T cells are generated directly inside the patient's body, seeks to overcome these challenges by eliminating the need for ex vivo cell processing and complex logistics, as well as improve clinical performance. Recent advances in virology, RNA …
