Modulation of human dorsal root ganglion neuron firing by the Nav1. 8 inhibitor suzetrigine
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RG Stewart, T Osorno, A Fujita, S Jo…
Proceedings of the …, 2025
pnas.org
Nav1. 8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1. 8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating acute pain in clinical trials. Nociceptors also express other sodium channels, notably Nav1. 7, raising the question of how effectively excitability of the neurons is reduced by inhibition of Nav1. 8 channels alone. We used VX-548 to explore this question, recording from dissociated human dorsal root ganglion neurons at 37° C. Applying …
