Pd/NBE Cocatalyzed Modular Synthesis of 3-Alkenyl-2, 3′-bisindoles and Applications in Access to Racemosin B
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W Zhang, M Hu, J Sun, J Yin, H Li, L Feng, J Gong…
Organic …, 2026
ACS Publications
A palladium/norbornene (NBE) cooperative catalysis for the modular, one-pot synthesis of 3-alkenyl-2, 3′-bisindoles from 3-iodoindoles and olefins is reported. This protocol enables the concurrent formation of the C2–C3′ bisindole linkage and a C3-alkenyl group, affording the desired products in high yields with a broad substrate scope. Density functional theory (DFT) calculations reveal that the addition of p-toluenesulfonic anhydride (Ts2O) accelerates the C–H activation step via an in situ anion exchange. The method′ s utility is showcased …
