期刊论文Bifonazole, a biochemist's view复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/6396116复制

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PMID: 6396116
作者: D Berg; M Plempel; D Berg; D Berg; M Plempel
摘要: Bifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. Compared to clotrimazole, the primary mode of action of these two antimycotics is accepted to represent inhibition of the cytochrome P450-dependent hydroxylation at the sterol-C14-methyl group, which is the first step in C14-demethylation reaction. At least in dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase, the starting and regulatory enzyme in terpenoid biosynthesis, whereas after appli...