Visible-Light Photoredox-Catalyzed Radical Addition/Double Cyclization of Indole with Alkenes: Access to gem-Difluorotetrahydrocarbazolones
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Z Yao, Y Wang, L Qi, J Guan, Y Tian…
The Journal of Organic …, 2026
ACS Publications
A visible-light photoredox-catalyzed one-pot tandem synthesis of gem-difluorotetrahydrocarbazolones from readily accessible N-alkenylindoles and ethyl bromodifluoroacetate (BrCF2CO2Et) has been developed. Notably, this protocol is also applicable to pyrrole-type substrates, enabling the efficient construction of the corresponding gem-difluorinated cyclic products. This transformation proceeds under ambient conditions, delivers high yields, shows outstanding functional group tolerance, and can be easily and …
