Proton craniospinal irradiation for patients with leptomeningeal metastasis: a randomized clinical trial
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JT Yang, D Yerramilli, E Pentsova, S Wolden…
JAMA …, 2025
jamanetwork.com
Importance Leptomeningeal metastasis (LM) is associated with limited survival and few treatment options. Photon involved-field radiotherapy (IFRT) is the most common radiotherapy treatment for patients with LM from solid tumors. Objective To assess whether proton craniospinal irradiation (pCSI) would result in superior central nervous system progression-free survival (CNS-PFS) compared with IFRT. Design, Setting, and Participants A randomized, phase 2 trial of pCSI vs IFRT was conducted between April 16, 2020, and …
