Synthesis of novel N-(2-hydroxyphenyl) arylsulfonamides as selective HDAC inhibitory and cytotoxic agents
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J Kim, P Chun, HR Moon
Bulletin of the Korean Chemical …, 2013
scholar.kyobobook.co.kr
Based on the finding that the 2-aminobenzamido group of MS-275 plays a crucial role in inhibiting HDACs through chelation of zinc existing at the active site of HDAC enzymes, novel N-(2-hydroxyphenyl) arylsulfonamide derivatives were synthesized for their potential ability to inhibit HDACs and evaluated for anticancer activity against human breast cancer cell line (MCF-7). Although the synthesized arylsulfonamides have failed to significantly inhibit total HDACs activity, phenyl carbamate-linked arylsulfonamide 10 and benzyl …
