Adamts-7—A new target for cardiovascular diseases treatment
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S YANG
Chinese Pharmaceutical Journal, 2018
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ABSTRACT A disintegrin-like and metalloprotease (ADAMTS) proteinases are a group of multidomains and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the cardiovascular diseases. In physically, ADAMTS-7 was involved in the growth and development of the body. However, in pathological conditions, over expression of ADAMTS-7 gene accelerated the progression of cardiovascular diseases through by promoting the breakdown of cartilage …
