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Discovery of potent and selective CK1α molecular degrader with a favorable safety profile for acute myeloid leukemia and solid tumors复制

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J Kong, J Park, H Lee, H Kang, D Lee, H Jo
Cancer Research, 2023
aacrjournals.org
… First, we demonstrated PIN-A1 can form a ternary complex with CK1α and CRBN using TR-…
of CK1α by PIN-A1 was also confirmed by global proteomics analysis. PIN-A1 induced rapid …

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