Serotonin 5-HT2C receptor signaling analysis reveals psychedelic biased agonism
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EM Bonniwell, R Alabdali…
ACS chemical …, 2025
pmc.ncbi.nlm.nih.gov
The serotonin 2C receptor (5-HT2C) is a G protein-coupled receptor implicated in multiple physiological and psychological processes and has been investigated as a therapeutic target for neuropsychiatric conditions such as obesity, drug abuse, and depression. With renewed interest in serotonergic psychedelics for treating depression, 5-HT2C may contribute to psychedelic-induced therapeutic effects. Despite earlier evidence of 5-HT2C G protein coupling promiscuity, the full signaling landscape remains incompletely …
