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EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (RAPAMYCIN) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …复制

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S Qi, D Xu, J Peng, MD Vu, J Wu, I Bekersky…
Transplantation, 2000
ovid.com
… Our previous studies confirmed that tacrolimus (FK506) and sirolimus [rapamycin (RAPA)],
in combination, are not antagonistic but are synergistic in the prolongation of heart and
small bowel grafts in the rodent. The aim of this study was to confirm further the synergistic
effect of combined FK506 and RAPA in the more clinically relevant model, kidney
transplantation in monkeys. … In contrast, our previous in vivo studies indicated that FK506
and RAPA in combination are not antagonistic but produce a synergistic effect in the …

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