Preclinical safety evaluation of intravenously administered mixed micelles.
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K Teelmann, B Schläppi, M Schüpbach…
Arzneimittel …, 1984
europepmc.org
Mixed micelles, with their main constituents lecithin and glycocholic acid, form a new principle for the parenteral administration of compounds which are poorly water-soluble. Their composition of mainly physiological substances as well as their comparatively good stability substantiate their attractivity in comparison to existing solvents. A decomposition due to physical influences such as heat or storage for several years will almost exclusively affect the lecithin component in the form of hydrolysis into free fatty acids and lysolecithin …
