The effect of particle size on bioavailability in cyclosporine preparations based on submicron dispersions
1. 请及时下载文件确认是否正确, 系统将在 2026-08-21 14:58:44 删除文件
2. 如若文件有误请驳回应助文件, 求助状态即回到求助中
3. 如若文件正确请及时点击确认, 若超过时后系统自动默认为已完结
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/12426767
其他信息:
PMID: 12426767
作者: A Vrána; T Andrýsek; A Vrána; A Vrána; T Andrýsek
摘要: The effect of particle size on bioavailability of 9 different formulations with cyclosporine A was studied. A common feature of all the formulations was the ability to form submicron dispersions under dilution. The composition of individual formulations was chosen in such a way that they were based on same or similar excipients. For each formulation, pharmacokinetic study was carried out in beagle dogs. On groups of 10 dogs, the average AUC was evaluated. Particle size of formulations under dilu...
