The effect of particle size on bioavailability in cyclosporine preparations based on submicron dispersions
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/12426767
其他信息:
PMID: 12426767
作者: A Vrána; T Andrýsek; A Vrána; A Vrána; T Andrýsek
摘要: The effect of particle size on bioavailability of 9 different formulations with cyclosporine A was studied. A common feature of all the formulations was the ability to form submicron dispersions under dilution. The composition of individual formulations was chosen in such a way that they were based on same or similar excipients. For each formulation, pharmacokinetic study was carried out in beagle dogs. On groups of 10 dogs, the average AUC was evaluated. Particle size of formulations under dilu...
