Construction of peptide library in mammalian cells by dsDNA-based strategy
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W Su, Y Wang, S Zou, Y Zhao, Y Li, C Zhang, X Guo…
ACS …, 2022
ACS Publications
While different display technologies, represented by phage display, have been widely used in drug discovery, they still can hardly achieve function-based peptide screening, which in most cases is performed in mammalian cells. And most attempts to screen functional peptides with mammalian platforms utilized plasmids to store coding information. Our previous work established double-stranded DNAs (dsDNAs) as innovative biological parts to implement AND-gate genetic circuits in mammalian cells. In the current study, we employ …
