Structure-Encoded Location Biased Signaling in a Class B GPCR: Focus on the PTH Type 1 Receptor
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KA Peña, JP Vilardaga
Pharmacology of GPCRs Biased Signaling and …, 2025
Springer
Research conducted over the last 15 years indicates that cAMP is generated not just from the plasma membrane but also from intracellular compartments, particularly in endosomes, where receptors are redistributed during the endocytosis process. This review centers on the parathyroid hormone type 1 receptor (PTH1R) as a model for a peptide hormone GPCRs that generates cAMP from various locations with distinct duration and pharmacological effectiveness. We discuss how structural dynamics simulations aid in designing ligands that …
