Boosting transcytosis-mediated tumor entrance of dendritic dots via two-nanometer dimension tuning
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DOI:
文献链接: 10.1016/j.cej.2026.177221
其他信息:
Z Wang, J Yang, Y Sun, Z Ye, Y Gu, Y Zhu…
Chemical Engineering …, 2026
Elsevier
AbstractThe entry of nanocarriers into solid tumors poses an intrinsic size paradox in enhanced permeability and retention (EPR)-mediated passive delivery: larger nanoparticles accumulate more but face diffusion barriers, while smaller ones penetrate deeper but are rapidly cleared. Transcytosis-mediated active penetration resolves this trade-off by evading diffusion resistance, realizing simultaneous efficient accumulation and deep penetration. Herein, we designed acetylated cyanine-cored dendritic dots (Gx-Ac, x= 5–8, 4.9–11.1 nm) …
