期刊论文Degradation of the ETS transcription factor ERG by stabilized helical peptide (Helicon™) degraders enables pharmacological validation in ERG-fusion prostate cancer …复制

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AK Luciano, B White, G Lambert, A Fulgham…
Cancer …, 2025
aacrjournals.org
Approximately 300, 000 new prostate cancer patient diagnoses and 35, 000 deaths due to prostate cancer are documented annually in the United States. An estimated 40-50% of all prostate cancers harbor the TMPRSS2-ERG fusion, leading to androgen receptor (AR)-driven expression of the oncogene ERG. As a transcription factor, ERG induces tumorigenesis by increasing cell proliferation and both invasion and migration of tumor cells, promoting their metastatic ability. ERG and AR have interconnected functions in prostate …