Unexpected Activities of CYP152 Peroxygenases Toward Non‐carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility
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Y Jiang, P Gong, Z Li, Z Li, Y Li, B Wang…
Angewandte …, 2025
Wiley Online Library
Exploring and exploiting the catalytic promiscuity of enzymes is a central topic and captivating challenge in enzymology. CYP152 peroxygenases are attractive biocatalysts for diverse reactions under mild conditions using H2O2 as cofactor. However, their substrate scope is limited by a carboxyl group required for substrate assisted acid‐base catalysis, following the well‐accepted principle that heme‐dependent H2O2‐utilizing enzymes employ a carboxyl group within their active sites to facilitate H2O2 activation. Herein, we reveal for …
