Hyperplasia of juxtaglomerular cells and renin localization in kidney of normotensive animals given captopril. Electron microscopic and immunohistochemical studies
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/7046618
其他信息:
PMID: 7046618
作者: F G Zaki; G R Keim; Y Takii; T Inagami; F G Zaki; ...
摘要: Captopril, a competitive inhibitor of angiotensin I-converting enzyme (ACE), is an orally potent antihypertensive agent. Light and electron microscopic studies of th kidneys of mice, rats, and monkeys given large oral doses of captopril for long duration were conducted. All mice and some rats and monkeys developed hyperplasia of the renin-secreting cells which appeared in several layers surrounding the vascular wall of the afferent arterioles. In the electron microscope, these epithelioid cells ...
