Effects of different B-cell-depleting strategies on the lymphatic tissue
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/40651933/
其他信息:
C Tur, M Eckstein, L Bucci, J Auth, C Bergmann…
Annals of the Rheumatic …, 2025
Elsevier
Objectives To assess the efficacy of new protein-based B cell depletion with glyco-engineered anti-CD20 antibody obinutuzumab (OBI) and the CD19/CD3 T cell engager blinatumomab (BLI) in patients with autoimmune diseases (AIDs) in comparison to rituximab (RTX) and CD19 chimeric antigen receptor (CAR) T cell therapy. Methods Sequential inguinal lymph node biopsies were taken before and after treatment with OBI-, BLI-, RTX-and CD19-CAR T cells in patients with AID. CD19 and CD20 B cells, plasma cells, T cells …
