The pharmacokinetics of ibuprofen in humans and animals
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F Jamali, DR Brocks
Ibuprofen: Discovery, Development and …, 2015
Wiley Online Library
The pharmacokinetic properties of ibuprofen have been studied intensely. It was the first 2‐arylpropionic acid (2‐APA) non‐stereoidal anti‐inflammatory drug (NSAID) developed and marketed for treatment of arthritic disorders, and in many countries it has been granted non‐prescription status for treatment of pain and fever. Most oral formulations of ibuprofen display almost complete systemic bioavailability, regardless of their rate of absorption. Similarly to other NSAIDs, ibuprofen displays extensive (99%) binding to plasma proteins. Non‐linear …
