The A986S calcium sensing receptor variant supports the adaptation of breast cancer cells to high calcium—a novel paradigm in breast cancer progression
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N Sakwe, N Sakwe, P Black, D Ball, Q Wang…
…, 2024
journals.physiology.org
Breast cancer and other solid tumors that metastasize to bone are frequently accompanied by a progressive increase in circulating calcium as the disease becomes more malignant. The increase in circulating calcium not only disrupts systemic calcium homeostasis but also alters the ability of cells to sense slight changes in extracellular Ca2+ via the ubiquitous calcium sensing receptor (CaSR). Of the CASR polymorphisms at rs1801725 (p. A986S), rs1801726 (p. Q1011E), and rs1042636 (p. R990G) in exon 7 of the receptor, previous …
