Effects of CVA21, an Oncolytic Virus, in Combination with Pembrolizumab on Immunogenicity and the Tumor Microenvironment in Advanced NSCLC: A Phase I/II Trial
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A Balasubramanian, C Marceaux, S Kanwal…
Clinical Cancer …, 2025
aacrjournals.org
Purpose: Acquired or de novo resistance to immune checkpoint inhibitors occurs in the majority of advanced non–small cell lung cancers. There is an unmet need to improve outcomes for patients with this condition. Oncolytic viruses represent an attractive treatment approach because of their dual activity in inducing tumor cell lysis directly and potentially augmenting antitumor immunity. In this study, we present the safety, efficacy, and translational findings from a phase I/II single-arm trial utilizing CVA21, an oncolytic …
