CS12192 Reverses Alopecia Areata by Selectively Targeting JAK3/JAK1/TBK1
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H Jin, Z Li, X Li, Q Xu, B Chen, S Shan, D Pan…
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Wiley Online Library
The approval of JAK inhibitors, represented by baricitinib, for the treatment of alopecia areata (AA) has ushered in a new era. However, their excessive immunosuppressive effects have also raised numerous concerns. Therefore, the development of JAK inhibitors with different selectivities may enhance drug safety while maintaining therapeutic efficacy. CS12192, developed by our team, is a selective JAK3 inhibitor that also partially inhibits JAK1 and TBK1. In this study, we evaluate the effectiveness of CS12192 and baricitinib in a …
