Preclinical evaluation, and clinical translation of 68Ga/177Lu-JH04, a novel FAP-targeting radiolabeled agent
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Y Yang, H Cheng, Y Lai, X Lin, Y Yu, J Zhan…
Cancer …, 2025
aacrjournals.org
Introduction: Fibroblast activation protein (FAP) is an ideal target for tumor imaging and therapy. To enhance tumor uptake and prolong the retention of FAP-targeting agents, we developed JH04, a novel cyclic peptide composed of a FAP-targeting ligand. The objective of this study is to evaluate the specificity, biodistribution, pharmacokinetics, and dosimetry of 68Ga/177Lu-JH04 through preclinical and preliminary clinical investigations, and to compare these findings with those of 68Ga/177Lu-FAP-2286. Methods: The FAP-positive …
