Influence of polymer molecular weight on in-vitro characteristics and cytotoxicity of fulvestrant loaded nanoparticles
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C Hascicek, CT Sengel-Turk, M Gumustas…
Current Drug …, 2014
ingentaconnect.com
The objective of this research was to fabricate a novel polymeric nanoparticulate system of Fulvestrant (FLV) and investigate the effect of polymer molecular weight variation on in vitro properties and also anti-proliferative potency of the carriers. Two different forms of polymerspoly (lactic-co-glycolic acid)(PLGA) were employed for the fabrication of polymeric nanoparticles (PNPs) by using a combination of diffusion-emulsification-salting out preparation procedure. In vitro evaluation of the PNPs was performed in terms of entrapment …
