DNA binding studies of Vinca alkaloids: experimental and computational evidence
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/22545401
其他信息:
PMID: 22545401
作者: Prateek Pandya; Surendra P Gupta; Kumud Pandav; Ritu Barthwal; B Jayaram; ...
摘要: Fluorescence studies on the indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine and catharanthine have demonstrated the DNA binding ability of these molecules. The binding mode of these molecules in the minor groove of DNA is non-specific. A new parameter of the purine-pyrimidine base sequence specificty was observed in order to define the non-specific DNA binding of ligands. Catharanthine had shown
