Loss of SMARCA4 Leads to an Impaired Hematopoiesis in Mice
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F Modemann, L Ramke, E Erdal, M Schoof, C Göbel…
Blood, 2023
Elsevier
SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a) is the central ATPase containing enzyme in the SWI/SNF-(switch/sucrose non-fermentable) complex, which regulates chromatin accessibility and thereby influences gene transcription. By acting as a transcriptional activator or repressor in different cell types, SMARCA4 and the SWI/SNF complex have various functions. Our aim was to understand the function of SMARCA4 in healthy hematopoiesis in order to then apply our findings to …
