Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification
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X Ba, M Dehghany, D Mortensen…
RSC Medicinal …, 2026
pubs.rsc.org
The field of targeted protein degradation has garnered significant attention over the past two decades, highlighted by the FDA approval of several therapeutics and the entry of numerous drug candidates into clinical development, the majority of which are cereblon (CRBN) based therapeutics. Synthetic strategies to access these modalities have evolved from low-yield, multi-step syntheses to more efficient methodologies emphasizing late-stage and/or one-step functionalization. In this review, we discuss 21 recently published literature studies …
