NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
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Y He, MY Zeng, D Yang, B Motro, G Núñez
Nature, 2016
nature.com
Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins,. The NLRP3 inflammasome has been implicated in the pathogenesis of several acquired inflammatory diseases, as well as cryopyrin-associated periodic fever syndromes (CAPS) caused by inherited NLRP3 …
