Crystalline modifications of ampicillin I: the trihydrate
DOI:
文献链接: https://www.nature.com/articles/220168a0
其他信息:
MNG James, D Hall, DC Hodgkin
Nature, 1968
nature.com
WE report the existence of the zwitterionic form of 6-[d (−) α-aminophenylacetamido] penicillanic acid (I; ampicillin) in the crystalline trihydrate. The synthesis of ampicillin and of related acid stable α-substituted benzyl-penicillins has been reported by Doyle et al. 1. Ampicillin has been shown to crystallize in two forms depending on the temperature of the aqueous solution from which crystallization is initiated2. The anhydrous modification is obtained by crystallization from an aqueous solution at temperatures above 60° C, whereas …
