Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/7562518
其他信息:
PMID: 7562518
作者: D Wu; S V Otton; W Kalow; E M Sellers; D Wu; ...
摘要: One of the potential problems of using dextromethorphan as a neuroprotective or anticonvulsant agent is the phencyclidine-like behavioral effects that have been attributed to its major metabolite dextrorphan. Because previous behavioral studies of dextromethorphan have generally failed to consider metabolic conversion to this metabolite, the present studies were conducted to examine the effects of route of administration on dextromethorphan pharmacokinetics and locomotor activity in the rat. The...
