Histidine as a versatile excipient in the protein-based biopharmaceutical formulations
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JY Lv, RG Ingle, H Wu, C Liu, WJ Fang
International Journal of …, 2024
Elsevier
Adequate stabilization is essential for marketed protein-based biopharmaceutical formulations to withstand the various stresses that can be exerted during the pre-and post-manufacturing processes. Therefore, a suitable choice of excipient is a significant step in the manufacturing of such delicate products. Histidine, an essential amino acid, has been extensively used in protein-based biopharmaceutical formulations. The physicochemical properties of histidine are unique among amino acids and could afford multifaceted benefits …
