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Long-lasting interaction study between RPL554 and glycopyrronium bromide on human isolated bronchi复制

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L Calzetta, M Cazzola, C Page…
European …, 2014
publications.ersnet.org
Background: The acute relaxant synergistic interaction between RPL554 and anticholinergic agents has been recently proved on human isolated bronchi (Calzetta, L. et al. J Pharmacol Exp Ther. 2013; 346: 414-23). Aim: To investigate the long-lasting interaction between RPL554 and glycopyrronium in human isolated bronchi. Methods: Bronchial rings from 6 patients were incubated in Krebs-Henseleit solution (37° C) aerated with O 2/CO 2 (95/5%) under 0.5–1.0 g tension. The duration of action (30% maximal relaxation, EC 30) of RPL554 …

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